From Bcg/Lsh/Ity to Nramp1: three decades of search and research.
نویسندگان
چکیده
Gene identification in the pre-genomic era was often arduous, and the mouse Nramp1 gene (natural resistance-associated macrophage protein 1; formerly the Bcg/Lsh/Ity locus) was no exception. Yet, the three decades of gene search and research which have encompassed Nramp1 can be viewed as a journey that produced not one, but many discoveries. In this review, we provide a brief history of the Nramp1 gene, its discovery and the ongoing efforts to characterize the role of the mouse and human NRAMP1 genes in susceptibility to mycobacterial infections.
منابع مشابه
The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene
In mice, natural resistance or susceptibility to infection with intracellular parasites is determined by a locus or group of loci on chromosome 1, designated Bcg, Lsh, and Ity, which controls early microbial replication in reticuloendothelial organs. We have identified by positional cloning a candidate gene for Bcg, Nramp1, which codes for a novel macrophage-specific membrane transport protein....
متن کاملNramp1 transfection transfers Ity/Lsh/Bcg-related pleiotropic effects on macrophage activation: influence on antigen processing and presentation.
The natural resistance-associated macrophage protein (Nramp1) regulates macrophage activation. One of its pleiotropic effects on macrophage function is to regulate expression of major histocompatibility class II molecules. In this study macrophages stably transfected with the wild-type (infection-resistant) or the natural mutant (infection-susceptible) allele of the Nramp1 gene were used to stu...
متن کاملEvidence inconsistent with a role for the Bcg gene (Nramp1) in resistance of mice to infection with virulent Mycobacterium tuberculosis
The superior resistance of some strains of mice over others to infection with certain intracellular pathogens, including the vaccine strain of Mycobacterium bovis, bacillus Calmette Guerin (BCG), is determined by a gene associated with a small segment of chromosome 1 designated by Ity/Lsh/Bcg locus, referred to here as the Bcg locus. DBA/2 mice containing the dominant resistant allele of the Bc...
متن کاملNatural Resistance to Infection with Intracellular Pathogens: The Nramp1 Protein Is Recruited to the Membrane of the Phagosome
The Nramp1 (natural-resistance-associated macrophage protein 1) locus (Bcg, Ity, Lsh) controls the innate resistance or susceptibility of mice to infection with a group of unrelated intracellular parasites which includes Salmonella, Leishmania, and Mycobacterium. Nramp1 is expressed exclusively in professional phagocytes and encodes an integral membrane protein that shares structural characteri...
متن کاملFunctional analysis of the human NRAMP family expressed in fission yeast.
The Bcg/Ity/Lsh locus in the mouse genome regulates macrophage activation for antimicrobial activity against intracellular pathogens, and the positional cloning of this locus identified the Nramp1 (natural resistance-associated macrophage protein) gene. Nramp2 was initially isolated as a homologue of Nramp1. Recently, the rat divalent metal transporter DMT1 was identified electrophysiologically...
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عنوان ژورنال:
- Drug metabolism and disposition: the biological fate of chemicals
دوره 29 4 Pt 2 شماره
صفحات -
تاریخ انتشار 2001